The controversial star will be attending a VIP boxing dinner at The Centre, in Farnham Road, tonight.
The self-professed 'baddest man on the planet' will give a talk and host a question and answer session.
There will be a raffle and an auction for boxing memorabilia.
Azar Khan, promoter at Elite Boxing Promotions, said: "We've done different shows with Mike up and down the country and we thought the people of Slough would want a piece of Mike. He will spend a couple of days in Slough."
The company are selling sponsorship packages as well as tickets - which range from £75 to £250 for a VIP pass. Limited tickets are available.
To book corporate sponsorship, call 07404 196454 or for ticket sales call 07884 414673.